"...a cow which defecates in the middle of the road, (we) cannot take legal action against it because it has no brain and cannot think," said Nik Aziz who is the spiritual leader of the country's Pan-Islamic Party (PAS).
"But human beings, who have brains, for them to do something which is wrong in religion ... when they are in an attire which symbolizes Islam, they can be regarded as being more despicable than cows," he said on Friday, according to Malaysia's state news agency Bernama.
PAS is one of the three parties in Malaysia's opposition alliance led by former deputy prime minister Anwar Ibrahim.
Nik Aziz said that smoking was forbidden by Islam.
Recently, Indonesia's top Islamic body passed a fatwa or ruling banning smoking. Malaysia's top Islamic body has also banned smoking.
Despite the ban in Malaysia, where over half the population of 27 million is Muslim, 50 percent of the male population smokes according to World Health Organization (WHO) data.